William W. Sutherling, M.D.
Medical Director, Epilepsy and Brain Mapping Program
Education Degree Field of Study
Georgetown University, Washington, D.C. B.S. (1968) Liberal Arts
University of Virginia, Charlottesville, VA M.D. (1976) Medicine
Mayo Clinic, Rochester, MN Resid. Fellow (1980-81) Neurology/EEG
UCLA Fellowship (1981-82) Epilepsy
UCLA Teacher/Invest. (1983-88) Dipole Local in MEG
Professional Experience
1981 - 1992 Assistant Director, Epilepsy Monitoring Unit, UCLA
1981 - 1989 Assistant Professor of Neurology, UCLA
1982 - 1990 Associate Examiner, American Board of Clinical Neurophysiology
1985 - 1992 Director, Neuromagnetism Lab, Subdural Grid Program, UCLA
1990 - 1992 Associate Professor of Neurology, UCLA
1990 - 1992 Facilitator, American Academy of Neurology Assessment of Magnetoencephalography
1991 - 1993 Chairman, Subcommittee on Magnetoencephalography, American EEG Society
1992 - present Medical Director, Epilepsy and Brain Mapping Program
1992 - 1997 Medical Dir., Neuromagnetism Lab, Neuroscience Institute, Hospital of the Good Samaritan
1992 - 1997 Member, Board of Directors, Neuroscience Institute, Hospital of the Good Samaritan
1993 - 1997 Member Neurology A Study Section, NIH
1997 - present Ad Hoc Reviewer, NIH
1997 - present Director, Neuromagnetism Lab, Huntington Medical Research Institutes, Pasadena, California
1997 - present Director, Brain Mapping Unit, Huntington Memorial Hospital, Pasadena, CA
       
Certifications
1981 Diplomate, American Board of Clinical Neurophysiology
1982 Diplomate, American Board of Psychiatry and Clinical Neurology
       
Memberships
American Academy of Neurology Society for Neuroscience
American Assoc. for the Advancement of Science American EEG Society
New York Academy of Sciences American Epilepsy Society
       
Research Projects Ongoing or Completed During the Last 3 Years

Project:
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Type:
Duration:
Purpose:

"Magnetoencephalogram in Epilepsy"
William W. Sutherling, M.D.
NIH
RO1 NS20806
4/1/95-3/31/01 (administrative extension 4/1/98-3/31/01)
To measure the magnetic and electric fields of human epilepsy, to localize non-invasively the epileptogenic zone.
   
Project:
Principal Investigator:
Agency:
Type:
Duration:
Purpose:		 "Whole Head Neuromagnetometer"
William W. Sutherling, M.D.
National Center for Research Resources
NCRR 1 S10 RR 12018
9/30/97-9/29/98
Shared instrumentation grant which will be located in MSR of NS20806
   
Project:
Principal Investigator:
Agency:
Type:
Duration:
"MEG Research"
William W. Sutherling, M.D.
Huntington Memorial Hospital
private non-profit donation
11/1/97-10/31/00
 
Selected Publications

Barth DS, Sutherling W, Engel J, Beatty J."Neuromagnetic localization of epileptiform spike activity in the human brain." Science 1982. 218:891-894.

Cahan LD, Sutherling WW, McCullough MA, Rausch R, Engel J, Crandall PH. "Review of the 20-year UCLA experience with surgery for epilepsy." Cleveland Clinic Quarterly 1984. 55:1-12.

Barth, DS, Sutherling WW, Engel J, Beatty J. "Neuromagnetic evidence of spatially distributed sources underlying epileptiform spikes in the human brain." Science 1984. 223:293-296.

Barth DS, Sutherling WW, Beatty J."Fast and slow magnetic phenomena in focal epileptic seizures." Science 1984. 226:855-857.

Barth DS, Sutherling WW, Beatty J, "Massed intracellular currents of interictal penicillin spikes: evidence from neuromagnetic recording." Brain Research 1985. 368:36-48.

Barth DS. Sutherling W. Broffman J. Beatty J. "Magnetic localization of a dipolar current source implanted in a sphere and a human cranium." Electroenceph clin Neurophysiol 1986. 63:260-273.

Sutherling WW, Crandall PH, Engel J, Darcey TM, Cahan LD, Barth DS. "The magnetic field of complex partial seizures agrees with intracranial localizations." Ann Neurol 1987. 21:548-558.

Sutherling WW, Barth DS. "Selective electrode triggering of averaged magnetic data reduces the constraints of the inverse problem of neuromagnetic localization: a principle of relativity in the nervous system due to finite conduction delays." PhyMed Biol. 1987. 32:143.

Barth DS, Sutherling W. "Current source-density and neuromagnetic analysis of the direct cortical response in rat cortex." Brain Research 1988. 450:280-294.

Sutherling W, Crandall P, Darcey T, Becker D, Levesque M, Barth D. "The magnetic field of epileptic spikes agrees with intracranial localizations in complex partial epilepsy." Neurology 1988. 38:778-786.

Sutherling W, Crandall P, Darcey T, Becker D, Levesque M, Barth D. "The magnetic and electric fields agree with intracranial localizations of somatosensory cortex." Neurology 1988. 38:1705-1714.

Sutherling WW, Barth DS. "Neocortical propagation in temporal spike foci on MEG and EEG." Ann Neurol 1989. 25:373-381.

Barth DS, Baumgartner C, Sutherling WW. "Neuromagnetic field modeling of multiple brain regions producing interictal spikes in human epilepsy." Electroenceph Clin Neurophysiol 1989. 73:389-402.

Baumgartner, C, Sutherling, WW, Di, S, Barth, DS. "Investigation of multiple simultaneously active brain sources in the electroencephalogram." J. Neuroscience Methods 1989. 30:175-184.

Sutherling WW, Risinger MW, Crandall PH, Becker DP, Baumgartner C, Cahan LD, Barth DS, Levesque MF. "Focal functional anatomy of dorsolateral fronto-central seizures." Neurology 1990. 40:87-98.

Baumgartner, C, Barth DS, Levesque M, Sutherling WW. "Functional anatomy of human hand sensorimotor cortex from spatiotemporal analysis of electrocorticography." Electroenceph Clin Neurophysiol 1991. 78:56-65.
Baumgartner, C, Sutherling WW, Di S, Barth, DS. "Spatiotemporal modeling of cerebral evoked magnetic fields to median nerve stimulation." Electroenceph Clin Neurophysiol 1991. 70:27-35.

Henry TR, Sutherling WW, Engel J Jr, Risinger MW, Levesque MF, Mazziotta JC, Phelps ME. "Interictal cerebral metabolism in partial epilepsies of neocortical origin." Epilepsy Res 1991. 10:174-182.

Baumgartner C, Barth, DS, Levesque M, Sutherling WW. "Human hand and lip sensorimotor cortex as studied on electrocorticography." Electroenceph clin Neurophysiol 1992. 84:115-126.

Sutherling WW, Levesque M, Baumgartner C. "Cortical sensory representation of the human hand: Size of finger regions and non-overlapping digit somatotopy." Neurology 1992. 1020-1028.

Baumgartner C, Doppelbauer A, Sutherling WW, Zeitlhofer J, Lindinger G, Lind C, Deecke L. "Human somatosensory cortical finger representation as studied by combined neuromagnetic and neuroelectric measurements."Neurosci Ltrs 1991:134:103-108.

Baumgartner C, Doppelbauer A, Deecke L, Barth DS, Zeitlhofer J, Lindinger G, Sutherling WW. "Neuromagnetic investigation of somatotopy of human hand somatosensory cortex." Exp Brain Res 1991. 87:641-648.

Baumgartner C, Doppelbauer A, Sutherling WW, Lindinger G, Levesque MF, Aull S, Zeitlhofer J, Deecke L."Somatotopy of human hand somatosensory cortex as studied in scalp AD." Electroenceph clin Neurophysiol 1993. 88:271-9.

Vickrey BG, Hays RD, Rausch R, Sutherling WW, Engel J Jr, Brook RH. "Quality of life of epilepsy surgery patients compared to outpatients with hypertension, diabetes, heart disease, and/or depressive symptoms." Epilepsia 1992. 58:168-71.

Sutherling WS, Cuffin BN, Hari R, Harner RN, King DW, Mattson RH, Reite ML, Sato S, Weinberg H. "Assessment: magnetoencephalography (MEG)." Report of the Therapeutics and Technology Assessment Subcommittee. American Academy of Neurology. Neurology 1992. 42:1-4.

Sutherling WW, Levesque MF, Peacock W, Shields D, Shewmon A. "Presurgical Evaluation: Los Angeles, California, Epilepsy Surgery Program," UCLA. In: Lüders H, ed. Epilepsy Surgery. New York: Raven Press, 1992. 792-795.

Nakasato N, Levesque MF, Barth DS, Baumgartner C, Rogers RL, Sutherling WW. "Comparisons of MEG, EEG, and ECoG source localization in neocortical partial epilepsy in humans." Electroenceph. Clinical Neurophysioll. 1994. 171:171-178.

Rogers RL, Basile LFH, Taylor SA, Sutherling WW, Papanicolaou AC. "Somatosensory evoked fields and potentials following tibial nerve stimulation." Neurology 1994. 44:1283-1286.

Akhtari M, McNay D, Mandelkern M, Teeter B, Cline HE, Malik J, Clark G, Tatar R, Lufkin R, Rogers RL, Sutherling WW. "Somatosensory evoked response source localization using actual cortical surface as the spatial constraint." Brain Topography 1995. 7:63-69.

Gharib SA, Sutherling WW, Nakasato N, Barth DS, Baumgartner C, Alexopoulos N, Taylor S, Rogers RL. "MEG versus ECoG localization accuracy test." Electroenceph. Clin Neurophys. 1995. 94:109-114.

McNay D, Michielssen E, Akhtari M, Rogers RL, Taylor SA, Sutherling WW. "Multiple source localizaton using genetic algorithms." Journal of Neuroscience Methods. 1996. 64:163-172.

Rogers RL, Basile LFH, Bourbon WT, Taylor S, Sutherling WW, Papanicolaou AC. "Laterality of hippocampal responses to infrequent and unpredictable omissions of visual stimuli." Brain Topography 1996. 9:15-20.
Seymour KJ, Bluml S, Sutherling J, Sutherling W, Ross B. "Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet." MAGMA 8 (1999) pp 33-42.

Akhtari M. Bryant HC, Mamelak AN, Heller L. Shih JJ, Mandelkern M. Matlachov A. Ranken DM. Best ED and Sutherling WW. "Conductivities of Three-Layer Human Skull." Brian Topography, Vol 13, No. 1, Fall 2000: pp 29-42.

Akhtari M, Rogers RL. Mandelkern M, Taylor SA, Sutherling WW. "Cortical mapping of somatosensory evoked magnetic fields constrained by MRI segmentation." In: Biomag 96: Proceedings of the Tenth International Conference on Biomagnetism, C. Aine. Okada Y, Stroink G. Withernby SJ, Wood SJ, Wood CC. Editors. 2000. Springer-Verlag: New York.

Taylor SA, Rogers R, McNay D, Levesque M, Akhtari M, Sutherling W. "Optimization of conductivity and permeability parameters for brain CSF, skull and scalp using implanted sources in the human cranium." In Aine CJ, Okada G. Stroink SJ, Swithenby CC, Wood (Eds), Biomag 96: Proceedings of the Tenth International Conference on Biomagnetism.Springer-Verlag, New York.2000 pp 358-360.

Sutherling WW, Arthur D, Mosher JD, Leahy RM, Akhtari M, Mamelak AN, Lopez N, Radilla R, Sutherling JEN, Eto R, Huf R, Maleeva T, "Localization precision of whole cortex neuromagnetometer system for human epilepsy studies." American Epilepsy Society/American Clinical Neurophysiology Society Annual Meeting, 2000.

Shattuck D, Sutherling WW, Leahy R. "Improved cortical MRI segmentation of brains with intracranial grid electrodes." 7th Annual Meeting; Human Brain Mapping, Brighton, U.K., June 2001.

Mamelak AN, Lopez N, Akhtari M, Sutherling WW. "Magnetoencephalography directed surgery for neocortical epilepsy and central tumors." Submitted to Journal of Neurosurgery.

Sutherling WW, Akhtari M, Mamelak AN, Mosher J, Sands S, Weiss P, Lopez N, DiMauro M, Flynn E, Leahy R. "Dipole localization of human induced focal afterdischarge seizure in simultaneous magnetoencephalography and electrocorticography." Brain Topography in revision, 2001.
 
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