Adam M. Mamelak, M.D.
Neurosurgical Director, Epilepsy and Brain Mapping Program
Education Degree Field of Study
Tufts University B.S. (1985) Physics
Harvard Medical School M.D. (1990) Medicine
Professional Experience
1990 - 1996 Resident, Neurosurgery, Medicine, University of CA, San Francisco
1994 - 1995 Research Associate, Epilepsy Research Laboratory, Medicine, Univ.of CA, San Francisco
1995 - 1996 Chief Resident, Neurosurgery, University of California, San Francisco
1996 - 1997 Post-Doctoral Scholar, Biology, California Institute of Technology
1997 - present Assistant Professor and Section Head, Neurological Surgery, City of Hope
National Medical Center
1997 - present Staff Neurosurgeon & Director of Epilepsy Surgery, Huntington Memorial
Hospital
1997 - present Visiting Associate in Biology, California Institute of Technology
       
Honors and Professional Activities
1990 Sirgay Sanger Prize for best research paper related to the field of Psychiatry, Harvard Medical School
1990 Magna Cum Laude, Harvard Medical School
First Place, American College of Surgeons Committee on Trauma Residents Paper Competition, N. California Chapter
Sargeant at Arms Committee - Congress of Neurological Surgeons Annual Meeting
1996 Young Clinician Investigator Award, American Association Neurological Surgeons
1996 Junior Investigator Award, American Epilepsy Society
1996 National Brain Tumor Foundation AANS/CNS Award for Best Translational Research by a Practicing Neurosurgeon
1996-present Trauma Advisory Committee - Huntington Memorial Hospital
1997-present Medical Quality Task Force - City of Hope National Medical Center
1998- present National Comprehensive Cancer Network Clinical Guidelines Committee- CNS Task Force
1998-present Journal of Neuro-Oncology, Ad Hoc reviewer
2000 Neurosurgery Task Force, American Epilepsy Society
       
Memberships
American Association of Neurological Surgeons Joint Section on Tumors- AANS/CNS
American College of Surgeons Society for Neuro-Oncology
American Epilepsy Society
       
Research Projects Ongoing or Completed During the Last 3 Years

Project:
Funding
Principal Investigator:
Agency:
Type:
Duration:
Purpose:

"Tumor extent determination by rapid, magnetic resonance spectroscopic imaging"
$510,000 (6/98-6/03)
Adam N. Mamelak, M.D.
Intramural funding at City of Hope National Medical Center, Duarte CA
Pilot Study, NCRR 1 S10 RR 12018
9/30/97-9/29/98
Shared instrumentation grant which will be located in MSR of NS20806
   
Project:
Funding:
Principal Investigator:
Agency:
Type: 		"Neuronal Correlates of Learning and Memory"
$310,000 (4/98-2/02)
Erin M. Schuman, Ph.D.
Gimble Discovery Fund, California Institute of Technology
Developmental and Ongoing Project
   
Project:
Funding:
Principal Investigator:
Agency:
Type: 		"Time-lapse imaging of hippocampal re-organization following seizures"
$40,000 (6/98-6/99)
Adam N. Mamelak, M.D.
Research Foundation, American Association of Neurological Surgeons
Developmental
   
Project:

Principal Investigator:
Co-Investigators:
Agency:

Type: 		"Phase I trial of intrathecal Y90-DOTA-Anti-CEA antibodies for neoplastic meningitis"
Adam N. Mamelak, M.D.
Andrew Raubitschek, MD and Jefferey Wong, MD
National Cancer Institute (Radio-Immunotherapy Program Project Grant to City of Hope National Medical Center)
Pilot Clinical Trial
   
Project:

Funding:
Principal Investigator:
Co-Investigators:
Agency:
Type: 		"Phase I/II trial of interstitial 131I-TM-601 peptide infusion for patients w/ recurrent glioblastoma multiforme or anaplastic astrocytoma"
$180,000 (9/01-9/03)
Adam N. Mamelak, M.D.
Andrew Raubitschek, MD and Robert Morgan, MD
Transmolecular Industries, Inc., Corporate Sponsor
Pilot Clinical Trial
   
Project:


Funding:
Principal Investigator:
Co-Investigators:
Agency: 		"Efficacy of Vagus Nerve Stimulation on seizure control, quality of life, and medical cost in developmentally disabled patients living in an Intermediate Care facility (ICF-DD)"
$283,000 (12/00-6/03)
Roger Huf, MD
Adam N Mamelak, MD Kara Kneedy-Cayem, RN
Cyberonics, Inc. Corporate Sponsor
 
Selected Publications

Mamelak AN, Akhtari M, Lopez Z, Sutherling WW. Magnetoencephalography directed surgery for neocortical epilepsy and central tumors. Journal of Neurosurgery (submitted).

Tyszka JM, Mamelak AN. Volumetric multi-shot echoplanar spectroscopic imaging. Magnetic Resonance Medicine (In Press).

Shih CC, Weng Y, Mamelak AN, LeBon T, Hu M, Forman SJ. Human Neurohematopoetic stem cells in fetal brain. Blood (In Press).

Akhtari M, Bryant HC, Mamelak AN, Heller L, Shih JJ, Mandelkern M, Matlachov A, Ranken DM, Best ED, Sutherling WW.Conductivities of three-layer human skull. Brain Topography, Vol. 13(1):2-14.

Akhtari M, Flynn E, Taylor S, Mamelak AN, Sutherling WS. A cortical segmentation algorithm for constrained MEG dipole localization. Brain Topography (submitted).

Najbauer J, Schuman EM, Mamelak AN. The aspirin metabolite sodium salicylate causes focal cerebral hemorrhage and cell death in rats with kainic acid-induced seizures. Neuroscience. 99:1, 1-7-117, 2000.

Lin A, Bluml S, Mamelak AN. Nov 1999. Efficacy of 1H-magnetic resonance spectroscopy for clinical decision making in patients with suspected new or recurrent brain tumors. J. NeuroOncology. 45:69-81.

Mamelak AN, Eggerding FA, Oh DS, Wilson E, Davis RL, Spitzer R, Hay JA, Caton WL 3rd. Oct 1998. Fatal cyst formation after fetal mesencephalic allograft transplant for Parkinson's disease. Journal of Neurosurgery. 89:592-8.

Mamelak AN, Pitts LH, Damron S. Jul 1996. Predicting survival from head trauma 24 hours after injury: a practical method with therapeutic implications. Journal of Trauma. 41:91-9.

Mamelak AN, Fishman RA, Dillon WP, Wilson CB. Jul 1996. Spontaneous intracranial hypotension [letter; comment]. Journal of Neurosurgery. 85:192-3.

Mamelak AN, Dowd CF, Tyrrell JB, McDonald JF, Wilson CB. Feb 1996. Venous angiography is needed to interpret inferior petrosal sinus and cavernous sinus sampling data for lateralizing adrenocorticotropin-secreting adenomas. Journal of Clinical Endocrinology and Metabolism. 81:475-481.

Mamelak AN, Mampalam TJ, Obana WG, Rosenblum ML. Jan 1995. Improved management of multiple brain abscesses: a combined surgical and medical approach. Neurosurgery. 36(1):76-85.

Mamelak AN, Cogen PH, Barkovich AJ. Dec 1994. The 'filum intermedium' sign: focal in utero spinal cord infarct and extraspinal thecal sac. Case report. Journal of Neurosurgery. 81:941-6.

Mamelak AN, Obana WG, Flaherty JF, Rosenblum ML. Oct 1994. Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery. 35:622-31.

Mamelak AN, Prados MD, Obana WG, Cogen PH, Edwards MS. Jul 1994. Multicentric juvenile pilocytic astrocytoma: prevelance, risk factors for development, treatment option, and prognosis. Journal of Neurosurgery. 81:24-30.

Prados M, Mamelak AN. Jun 1994. Metastasizing low grade gliomas in children. Redefining an old disease [editorial]. Cancer. 73:2671-3.

Mamelak AN, Barbaro NM, Walker JA, Laxer KD. Nov 1993. Corpus callosotomy: a quantitative study of the extent of resection, seizure control, and neuropsychological outcome. Journal of Neurosurgery. 79:688-695.

Mamelak AN, Kelly WM, Davis RL, Rosenblum ML. Aug 1993. Idiopathic hypertrophic cranial pachymeningitis. Report of three cases and review of literature. Journal of Neurosurgery. 79:270-6.

Mamelak AN, Lopez N. Akhtari M, Sutherling WW. Magnetoencephalography directed surgery for neocortical epilepsy and tumors. Submitted to Journal of Neurosurgery.

Sutherling WW, Akhtari M, Mamelak AN, Mosher J, Arthur D, Sands S, Weiss P, Lopez N, DiMauro M, Flynn E, Leahy R, "Dipole localization of human induced focal afterdischarge seizure in simultaneous magnetoencephalography and electrocorticography."Brain Topography in revision, 2001.

Mamelak A., Quattrochi JJ, Hobson JA. A microcomputer-based system for automated collection and scoring of behavioral state in cats. Brain Research Bulletin 21(5):843-849, 1988.

Mamelak AN, Hobson JA. Nightcap: A home-based sleep monitoring system. Sleep 12(2):157-166, 1989.

Mamelak AN, Hobson JA. Dream bizarreness as the cognitive correlate of altered neuronal discharge during REM sleep. Journal of Cognitive Neuroscience 1(3):201-222, 1989.

Quattrochi JJ, Mamelak AN, Madison RD, Macklis JD, Hosbon JA. Mapping neuronal inputs to REM sleep induction sites with carbachol fluorescent microspheres. Science 245:984-986, 1989.

Yamamoto KI, Mamelak A, Quattrochi JJ, Hobson JA. A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: focus of the sensitive region. Neuroscience 39(2):279-293, 1990.

Mamelak AN, Quattrochi JJ, Hobson JA. Automated staging of sleep using neural networks. Electroencephalography and Clinical Neurophysiology. 79:52-61, 1991.

Quattrochi JJ, Mamelak AN, Binder D, Williams J, Hobson JA. Dynamic suppression of REM sleep by parenteral administration of the serotoni-1 agonist Eltoprazine. Sleep 15(2):125-132, 1992.

Quattrochi JJ, Mamelak AN, Binder D, Williams J, Hobson JA. Dose-related suppression of REM sleep and PGO waves by the serotonin-1 agonist Eltoprazine Neuropsychopharmoacology 8(1): 7-13, 1993.

Sutton JP, Mamelak AN, Hobson JA. Modeling states of waking and sleeping. Psychiatric Annals
22(3):137-143, 1992.

Mamelak AN, Mampalam TJ, Rosenblum ML. Brain abscesses: diagnosis and management.
Hospital Medicine 28(9):22-38, 1992.
 
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